{"product_id":"heme-plus-capsule","title":"Heme Plus","description":"\u003cp\u003eProduct Story\u003c\/p\u003e\n\u003c!-- tab content --\u003e\n\u003ch2\u003eActivated Iron + Cofactors†\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIron is a critical element for human physiology, acting as a component of hundreds of proteins and enzymes that support essential biological functions, such as oxygen transport, energy production, and DNA synthesis \u0026amp; repair. Many proteins \u0026amp; enzymes are dependent on iron as a cofactor and\/or structural component to function properly. Examples include the protein hemoglobin which red blood cells use to transfer oxygen rich blood from the lungs to the rest of the body as well as myoglobin which delivers oxygen to working muscles. Iron dependent enzymes include cytochromes in the electron transport chain inside mitochondria responsible for making energy in the form of adenosine triphosphate (ATP). Thyroid peroxidase (TPO) catalyzes is another iron containing enzyme that helps make thyroid hormone in the body which is crucial for energy production \u0026amp; metabolism. Without iron, DNA replication and repair would not occur since the enzymes responsible for these functions rely on iron to work properly. 1-6\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c!-- new tab --\u003e\n\u003cp\u003eSupplemental Facts\u003c\/p\u003e\n\u003c!-- tab content --\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2787\/5166\/files\/ScreenShot2021-10-08at1.31.48PM_480x480.png?v=1646953393\"\u003e\u003c\/div\u003e\n\u003cdiv style=\"text-align: left;\"\u003e\n\u003ch2\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/h2\u003e\n\u003c!-- new tab --\u003e\n\u003cp\u003eSuggested Use\u003c\/p\u003e\n\u003c!-- tab content --\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eSuggested Use:\u003c\/strong\u003e Take one (1) capsule daily with food or as recommended by your healthcare professional\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWARNING\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e: Accidental overdose of iron-containing products is a leading cause of fatal\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003epoisoning in children under 6. Keep this product out of reach of children. In case of\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eaccidental overdose, call a doctor or poison control center immediately.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFormulated To Be Free of Allergens Derived From: \u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003ewheat, soy, dairy, eggs, fish, crustacean shellfish, tree nuts, peanuts, artificial preservatives, sweeteners, color and flavors\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e†\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.\u003c\/span\u003e\u003c\/p\u003e\n\u003cbr\u003e \u003c!-- new tab --\u003e\n\u003cp\u003eResearch\u003c\/p\u003e\n\u003c!-- tab content --\u003e\n\u003ch2\u003eCitations\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Aggett PJ. Iron. In: Erdman JWJ, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Ames: Wiley-Blackwell; 2012:506-520.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Wessling-Resnick M. Iron. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and Disease. 11th ed: Lippincott Williams \u0026amp; Wilkins; 2014:176-188.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Winter WE, Bazydlo LA, Harris NS. The molecular biology of human iron metabolism. Lab Med. 2014;45(2):92-102. (PubMed)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Burmester T, Hankeln T. What is the function of neuroglobin? J Exp Biol. 2009;212(Pt 10):1423-1428. (PubMed)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Salminen A, Kauppinen A, Kaarniranta K. 2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process. Cell Mol Life Sci. 2015;72(20):3897-3914. (PubMed)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Zhang C. Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control. Protein Cell. 2014;5(10):750-760. (PubMed)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Food and Nutrition Board, Institute of Medicine. Iron. Dietary Reference Intakes for Vitamin A, Vitamin K, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, D.C.: National Academy Press; 2001:290-393. (National Academy Press)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Aggett PJ. Iron. In: Erdman JWJ, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Ames: Wiley-Blackwell; 2012:506-520.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Beard JL. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr. 2001;131(2S-2):568S-579S; discussion 580S. (PubMed)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Changela K, Haeri NS, Krishnaiah M, Reddy M. Plummer-Vinson syndrome with proximal esophageal web. J Gastrointest Surg. 2015;20(5):1074-1075. (PubMed)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Jauregui-Lobera I. Iron deficiency and cognitive functions. Neuropsychiatr Dis Treat. 2014;10:2087-2095. (PubMed)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Lee GR. Disorders of iron metabolism and heme synthesis. In: Lee GR, Foerster J, Paraskevas F, Greer JP, Rogers GM, eds. Wintrobe's Clinical Hematology. Baltimore: Williams and Wilkins; 1999:979-1070.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Semba RD, Bloem MW. The anemia of vitamin A deficiency: epidemiology and pathogenesis. Eur J Clin Nutr. 2002;56(4):271-281. (PubMed)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Allen LH. Iron supplements: scientific issues concerning efficacy and implications for research and programs. J Nutr. 2002;132(4 Suppl):813S-819S. (PubMed)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Semba RD, Bloem MW. The anemia of vitamin A deficiency: epidemiology and pathogenesis. Eur J Clin Nutr. 2002;56(4):271-281. (PubMed)\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003col start=\"16\"\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Allen LH. Iron supplements: scientific issues concerning efficacy and implications for research and programs. J Nutr. 2002;132(4 Suppl):813S-819S. (PubMed)\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003col start=\"17\"\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Suharno D, West CE, Muhilal, Karyadi D, Hautvast JG. Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in West Java, Indonesia. Lancet. 1993;342(8883):1325-1328. (PubMed)\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e","brand":"Aceva","offers":[{"title":"Auto Pack","offer_id":51897026642290,"sku":"CPK-HEM-30-1-ACV-O","price":6.6,"currency_code":"USD","in_stock":true},{"title":"AM Pack","offer_id":51897026675058,"sku":"CPK-HEM-30-1-ACV-O","price":6.6,"currency_code":"USD","in_stock":true},{"title":"PM Pack","offer_id":51897026707826,"sku":"CPK-HEM-30-1-ACV-O","price":6.6,"currency_code":"USD","in_stock":true},{"title":"Sleep Pack","offer_id":51897026740594,"sku":"CPK-HEM-30-1-ACV-O","price":6.6,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0857\/7761\/3115\/products\/cap.HemePlus.png?v=1706895545","url":"https:\/\/patientsubscriptions.com\/products\/heme-plus-capsule","provider":"Patient Subscriptions","version":"1.0","type":"link"}